EXAMINE THIS REPORT ON LSD CRYSTAL

While in the LSD-bound crystal framework, the facet chain on the lid residue L209EL2 types considerable hydrophobic contacts with both equally LSD and surrounding residues in TMs III, IV, and V (Figure 4C). Once the lid moved apart to show the binding pocket in simulation, quite a few of such contacts broke. We So hypothesized that L209EL2 acts to